男性45歲時某些類型的脫髮是患有前列腺癌的危險徵兆大綱
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來源：American Society ofClinical Oncology (ASCO)
美國臨牀腫瘤協會(ASCO)
New, large cohortanalysis from the prospective Prostate, Lung, Colorectal and Ovarian (PLCO)Cancer Screening Trial, indicates that men who had moderate baldness affectingboth the front and the crown of their head at age 45 were at a 40% increasedrisk of developing aggressive prostate cancer (usually indicates a fastergrowing tumor resulting in poorer prognosis relative to non-aggressive prostatecancer) later in life, compared to men with no baldness. There was nosignificant link between other patterns of baldness and prostate cancer study, published September 15 inthe Journal of Clinical Oncology, supports earlier research suggesting thatmale pattern baldness and prostate cancer may be linked.
一個新的，大型的潛在前列腺癌、肺癌、大腸癌和卵巢癌臨牀試驗篩選斷代分析表明，前額和頭頂頭髮在46歲時不斷掉落的男性與沒有脫髮的男性相比，以後患有侵略性前列腺癌的可能性增加40%（通常意味着沒有很好地診斷出非侵略性前列腺癌而造成的腫瘤的快速擴張），而別的部位脫髮則與患前列腺癌的風險沒有太大的關聯。這篇發表在9月15出版的《臨牀腫瘤學》上的文章證實了之前的研究結果，認爲男性某種類型脫髮可能與前列腺癌有關。
"Our study found anincreased risk for aggressive prostate cancer only in men with a very specificpattern of hair loss, baldness at the front and moderate hair-thinning on thecrown of the head, at the age of 45. But we saw no increased risk for any formof prostate cancer in men with other hair-loss patterns," said seniorstudy author Michael B. Cook, PhD, an investigator in the Division of CancerEpidemiology and Genetics at the National Cancer Institute in Bethesda, MD."While our data show a strong possibility for a link between thedevelopment of baldness and aggressive prostate cancer, it's too soon to applythese findings to patient care."
“我們的研究發現，只有某些特性類型的脫髮，頭前面和頭頂的頭髮在45歲時開始脫落，患侵略性前列腺癌的可能性增加。而其他類型的脫髮則與患前列腺癌的風險關係不大，”位於馬裏蘭州貝塞斯達的美國國家癌症研究所腫瘤流行病學和遺傳學部門的高級研究員、本文作者邁克爾·b·庫克博士說。“雖然我們的數據表明持續脫髮很可能與侵略性前列腺癌有關聯，但將這個發現應用於病人護理還爲時尚早。”Prostate cancer is thesecond most common cancer among men. Emerging evidence suggests that prostatecancer and male pattern baldness -- progressive scalp hair-loss in a distinctpattern -- are both connected to increased levels of male sex hormones(androgens) and androgen receptors, supporting the idea of a biological linkbetween baldness and prostate cancer development and progression.
前列腺癌是男性第二大常見癌症。新出現的證據表明前列腺癌和男性某種類型的脫髮—以一種特定的模式持續掉髮—與男性性激素(androgens)和性激素受體的水平增加都有關聯，表明脫髮與前列腺癌的發展和惡化存在着生物關聯。Researchers analyzed malepattern baldness in relation to prostate cancer risk in a cohort of 39,070 menfrom the U.S. PLCO Cancer Screening Trial, aged 55-74 years at enrollment. Themen received a questionnaire that asked them to recall what their hair-losspatterns were at age 45 using a pictorial tool.
研究人員對進行了美國前列腺癌臨牀試驗篩選的，登記在冊的，55到74歲的3萬9070名男性進行了男性某種類型脫髮與患前列腺癌的關聯進行了分析。這些男性接受了問卷調查，通過圖形工具回憶他們在45歲時的脫髮類型。During follow-up, 1,138prostate cancer cases were diagnosed, 51% of which were aggressive (Gleasonscore equal to or greater than 7, stage III or IV, or prostate cancer as thecause of death). The mean age at the time of prostate cancer diagnosis was 72.
接下來的隨訪表明，前列腺癌的確診病例的1138例，其中51%爲侵略性的（格里森評分等於或大於7,III期或IV期，或因前列腺癌病死）。診斷出前列腺癌的平均年齡爲72歲。Men who had a specificpattern of baldness, frontal and moderate crown (vertex), were 40% more likelyto develop aggressive prostate cancer, compared to men who had no e was no association between male pattern baldness and risk ofnon-aggressive prostate cancer.
前額和頭頂頭髮在46歲時不斷掉落的男性與沒有脫髮的男性相比，以後患有侵略性前列腺癌的可能性增加40%。而別的部位脫髮則與患前列腺癌的風險沒有太大的關聯Dr. Cook stated that ifthese findings are confirmed by further studies, medical assessment of baldnesscould possibly be used to help identify men who may be at increased risk ofaggressive prostate cancer. His research team is currently conducting twoadditional cohort analyses exploring the relationship between male patternbaldness and risk of developing and dying from prostate cancer. One of thestudies includes a baseline dermatologic assessment of male pattern baldness,which may be more reliable than the recall method, which was used in thepresent study. This research was supported by the intramural program of theU.S. National Cancer Institute, National Institutes of Health.
庫克博士認爲如果這個發現被進一步的研究所證實，那麼脫髮醫療審定可用來幫助識別患前列腺癌可能性增加的男性。他的研究團隊目前正在實施兩個補充的斷代分析，探索男性某種類型的脫髮與前列腺癌發展和惡化之間的聯繫。其中一個研究包括模式脫髮的頭皮層髮根評估，這比目前研究中使用的依靠回憶要可靠地多。此研究得到了美國國立衛生研究院、美國國家腫瘤研究所內部項目的資助。
